Mitochondrial DNA (mtDNA) variant pathogenicity interpretation has special considerations
given unique features of the mtDNA genome, including maternal inheritance, variant …

Mitochondria generate the energy to sustain cell viability and serve as a hub for cell
signalling. Their own genome (mtDNA) encodes genes critical for oxidative phosphorylation …

Modern humans have experienced explosive population growth in the past thousand years.
We hypothesized that recent human populations have inhabited environments with …

Shimao City is considered an important political and religious center during the Late
Neolithic Longshan period of the Middle Yellow River basin. The genetic history and …

We identified and dated 18 occupational events at eight sites dating to~ 14.7–10.8
kiloannum before present (ka BP) during a decade of archaeological survey and excavation …

Sherpa people, one of the high-altitude hypoxic adaptive populations, mainly reside in
Nepal and the southern Tibet Autonomous Region. The genetic origin and detailed …

Mitochondrial DNA (mtDNA) is a key player in numerous multifaceted and intricate biological
processes and plays a pivotal role in dissecting the peopling of different populations, due to …

Background As a mammal living at the highest altitude in the world, the yak has strong
adaptability to the harsh natural environment (such as low temperature, scarce food …

Objectives The aim of this study was to create a comprehensive summary of available
mtDNA and Y‐chromosome data for Native Americans from North, Central, and South …

Background Cytochrome oxidase subunit II is encoded by the MT-CO2 gene and belongs to
a large internal membrane complex called cytochrome c oxidase. To date, no pathogenic …