NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in
prokaryotes, and play crucial roles in a variety of biological processes, such as host defense …

Oxidative stress is a key pathologic factor in neurodegenerative diseases such as Alzheimer
and Parkinson diseases (AD, PD). The failure of free-radical-scavenging antioxidants in …

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human
pathogen. However, even in the setting of a robust neutrophil response, S. aureus can …

Abstract Significance: NADPH oxidases (Noxs), of which there are seven isoforms (Nox1–5,
Duox1/Duox2), are professional oxidases functioning as reactive oxygen species (ROS) …

Cutaneous leishmaniasis affects millions of people around the world. Several species of
Leishmania infect mouse strains, and murine models closely reproduce the cutaneous …

The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …

Glaucomatous optic neuropathy implies loss of retinal ganglion cells, including their axons,
and a major tissue remodeling, especially in the optic nerve head. Although increased …

Macrophages play an important role in the pathogenesis of chronic inflammatory disease.
Activation of these phagocytes induces the production of proinflammatory cytokines, such as …

Oxidative stress and amplified redox signaling contribute to the pathogenesis of many
human diseases including atherosclerosis. The superoxide-generating phagocytic NADPH …

During infection, macrophage lineage cells eliminate infiltrating pathogens through a battery
of antimicrobial responses, where the efficacy of these innate immune responses is pivotal …