Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

We present here a tutorial review on the electrospray mass spectrometry technique and its
applications to the study of drug-nucleic acid non-covalent complexes. Particular emphasis …

Organisms from all domains of life invest a substantial amount of energy for the introduction
of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA …

Protein radical labeling, like fast photochemical oxidation of proteins (FPOP), coupled to a
top-down mass spectrometry (MS) analysis offers an alternative analytical method for …

A combination of covalent labeling techniques and mass spectrometry (MS) is currently a
progressive approach for deriving insights related to the mapping of protein surfaces or …

Nucleic acids play key roles in the storage and processing of genetic information, as well as
in the regulation of cellular processes. Consequently, they represent attractive targets for …

Since 2016, eight new oligonucleotide therapies have been approved which has led to
increased interest in oligonucleotide analysis. There is a particular need for powerful …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

In this article, a perspective is given of chemical dynamics simulations of collisions of
biological ions with surfaces and of collision-induced dissociation (CID) of ions. The …

We have studied the effect of solution additives on hydrolysis and charge state distribution in
ESI MS of RNA. Lower and higher charge state ions can be electrosprayed from solutions …