The p53 tumor suppressor protein is a short-lived protein, which is stabilized in response to
cellular stress. The ubiquitination and degradation of p53 are largely controlled by Mdm2, an …

The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …

As p53 and its homologue p73 have significant sequence and functional similarities, p73
might also be expected to act as a tumour suppressor. However, p73 is activated after DNA …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

The tumor suppressor p53 is a central hub in a molecular network controlling cell
proliferation and death in response to potentially oncogenic conditions, and a wide array of …

The tumor suppressor protein p53 is negatively regulated by Mdm2, a ubiquitin ligase
protein that targets p53 for degradation. Mdmx (also known as Mdm4) is a relative of Mdm2 …

Based on gene sequence homologies, a p53 (TP53) gene family become apparent with the
addition of the most recently identified p63 (TP73L; formerly TP63) and p73 (TP73) genes to …

The human genome is far smaller than originally estimated, and one explanation is that
alternative splicing creates greater proteomic complexity than a simple count of open …

The murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor
suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of …

Introduction p53 continues to be one of the most intensively studied genes in cancer biology.
p53 was initially identified 20 years ago as a binding partner for the SV40 T oncoprotein …