Diapause is a protective mechanism that many organisms deploy to overcome
environmental adversities. Diapause extends lifespan and fertility to enhance the …

The TP53 gene is unarguably one of the most studied human genes. Its encoded protein,
p53, is a tumor suppressor and is often called the “guardian of the genome” due to its pivotal …

Whilst it is recognised that targeting self-renewal is an effective way to functionally impair the
quiescent leukaemic stem cells (LSC) that persist as residual disease in chronic myeloid …

Osteosarcoma has a poor prognosis, and the poor understanding of the genetic drivers of
osteosarcoma hinders further improvement in therapeutic approaches. Transcription factor …

Cell cycle progression is linked to transcriptome dynamics and variations in the response of
pluripotent cells to differentiation cues, mostly through unknown determinants. Here, we …

Precise regulation of the cell cycle of embryonic stem cells (ESCs) is critical for their self-
maintenance and differentiation. The cell cycle of ESCs differs from that of somatic cells and …

Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not
essential for mammalian development. Moreover, efforts to identify p53-dependent …

A minority of mouse embryonic stem cells (ESCs) display totipotent features resembling 2‐
cell stage embryos and are known as 2‐cell‐like (2C‐like) cells. However, how ESCs transit …

Previous reports have confirmed that saponins (ginsenosides) derived from Panax ginseng.
CA Meyer exerted obvious memory‐enhancing and antiaging effects, and the simpler the …

Cardiomyocytes in the adult human heart are quiescent and those lost following heart injury
are not replaced by proliferating survivors. Considerable effort has been made to …