Human physiology and pathology arise from the coordinated interactions of diverse single
cells. However, analyzing single cells has been limited by the low sensitivity and throughput …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC–MS/MS) is the
mainstay in proteome research because of its excellent sensitivity but often comes at the …

For several decades now, the analysis of steroids has been a key tool in the diagnosis and
monitoring of numerous endocrine pathologies. Thus, the available methods used to …

The SARS-CoV-2 Omicron (B. 1.1. 529) variant possesses numerous spike (S) mutations
particularly in the S receptor-binding domain (S-RBD) that significantly improve …

Abstract Ion Mobility Spectrometry (IMS) is a widely used technique for the post-ionization
separation and structural characterization of biomolecules. Trapped IMS (TIMS) is a …

Steroids play key roles in various biological processes and are characterized by many
isomeric variants, which makes their unambiguous identification challenging. Ion mobility …

Modern ion mobility instrumentation is typically operated above the low field limit, which may
activate the ions and cause structural rearrangement or fragmentation during analysis. Here …

Lanthipeptides belong to the family of ribosomally synthesized and post-translationally
modified peptides (RiPPs). The (methyl) lanthionine cross-links characteristic to …

The in-depth isomeric and isobaric description of ultra-complex organic mixtures remains
one of the most challenging analytical tasks. In the last two decades, ion mobility coupled to …