Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology

SJ Forrester, GW Booz, CD Sigmund… - Physiological …, 2018 - journals.physiology.org
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

[HTML][HTML] Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications

S Sakshi, R Jayasuriya, K Ganesan, B Xu… - … Therapy-Nucleic Acids, 2021 - cell.com
The majority of the non-protein-coding RNAs are being identified with diversified functions
that participate in cellular homeostasis. The circular RNAs (circRNAs) are emerging as …

[HTML][HTML] RETRACTED: Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta …

N Ghasemi Darestani, A Bahrami, MR Mozafarian… - Nutrients, 2022 - mdpi.com
The health benefits of omega-3 fatty acid (FA) supplementation on inflammatory gene
expression (IGE) and multiple sclerosis (MS) are becoming more evident. However, an …

Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124

J Chen, L Cui, J Yuan, Y Zhang, H Sang - Biochemical and biophysical …, 2017 - Elsevier
Increasing evidences have revealed the important role of circular RNAs (circRNAs) in
cardiovascular system disease. Whereas, the expression profiles and in-depth regulation of …

Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Y Tang, J Bao, J Hu, L Liu, DY Xu - Journal of cellular and …, 2021 - Wiley Online Library
Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non‐coding RNAs,
which exist widely in human tissues including the heart. Increasing evidence has shown that …

Salt-sensitivity of blood pressure and insulin resistance

LA Ertuglu, F Elijovich, CL Laffer, A Kirabo - Frontiers in Physiology, 2021 - frontiersin.org
Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular
morbidity and mortality that is seen in both hypertensive and normotensive populations …

Effects of DHA-enriched fish oil on gene expression levels of p53 and NF-κB and PPAR-γ activity in PBMCs of patients with T2DM: A randomized, double-blind, clinical …

Z Naeini, O Toupchian, A Vatannejad… - Nutrition, Metabolism …, 2020 - Elsevier
Abstract Background and Aims Omega-3 polyunsaturated fatty acids (PUFAs) are natural
peroxisome proliferator-activated receptor gamma (PPAR-γ) ligands. Activated PPAR-γ …

Role of the peroxisome proliferator activated receptors in hypertension

S Fang, MC Livergood, P Nakagawa, J Wu… - Circulation …, 2021 - Am Heart Assoc
Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …

LRP1 deficiency in vascular SMC leads to pulmonary arterial hypertension that is reversed by PPARγ activation

L Calvier, P Boucher, J Herz, G Hansmann - Circulation research, 2019 - Am Heart Assoc
Rationale: Arterial remodeling—a hallmark of many cardiovascular pathologies including
pulmonary arterial hypertension (PAH)—is regulated by TGFβ1 (transforming growth factor …

[HTML][HTML] Molecular mechanisms and genetic regulation in atherosclerosis

AO Jackson, MA Regine, C Subrata, S Long - IJC heart & vasculature, 2018 - Elsevier
Atherosclerosis (AS) manifested by lipid accumulation, extracellular matrix protein
deposition, and calcification in the intima and media of the large to medium size arteries …