Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …

Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …

Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

Nucleotide-binding leucine-rich repeat-containing proteins, or NOD-like receptors (NLRs),
are intracellular innate immune sensors that can regulate several signaling pathways …

GFP-like fluorescent proteins and their molecular mimics have revolutionized bioimaging
research, but their emissions are largely limited in the visible to far-red region, hampering …

Over the last decade, there has been significant advances in the understanding of the cross-
talk between metabolism and immune responses. It is now evident that immune cell effector …

Human innate immunity responds to viral infection by activating the production of interferons
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …

In the last years, proteomics has represented a valuable approach to elucidate key aspects
in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved …