The exonuclease torpedo Xrn2 loads onto nascent RNA 5′-PO 4 ends and chases down
pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to …

Abstract Paused RNA polymerase II (Pol II) that piles up near most human promoters is the
target of mechanisms that control entry into productive elongation. Whether paused Pol II is …

At the 3′ ends of protein-coding genes, RNA polymerase (Pol) II is dephosphorylated at
tyrosine residues (Tyr1) of its C-terminal domain (CTD). In addition, the associated cleavage …

Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the
polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation …

FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone
that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) …

Background: Gene expression microarrays' analyses provide a description of long
noncoding RNAs (lncRNAs) with lack of coding protein function that is often important in …

In a recent study, we investigated the regulation of hunchback (hb) transcription dynamics in
Drosophila embryos. Our results suggest that shutdown of hb transcription at early nuclear …

Transcription as the key step in gene expression is a highly regulated process. The speed of
transcription elongation depends on the underlying gene sequence and varies on a gene by …

Next-generation sequencing techniques allowed a better understanding of cancer
transcriptomes. Despite advancements, technical limitations still exist to fully decipher the …

Appropriate gene expression relies on the sophisticated interplay between genetic and
epigenetic factors. Histone acetylation and an open chromatin configuration are key features …