One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …

Many lines of evidence, ranging from in vitro experiments and pathological examinations to
epidemiological studies, show that inflammation is a cardinal pathogenetic mechanism in …

Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy,
which is the largest single cause of end‐stage renal disease and a medical catastrophe of …

Cytokines act as pleiotropic polypeptides regulating inflammatory and immune responses
through actions on cells. They provide important signals in the pathophysiology of a range of …

Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney
disease (CKD), often results in diffuse kidney scarring and predisposes to end-stage renal …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main
contributing factor for cardiovascular morbidity and mortality in patients with diabetes …

Diabetic kidney disease (DKD) is the leading cause of ESRD. We conducted an open-label,
prospective, randomized trial to determine whether pentoxifylline (PTF), which reduces …

The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

Renal fibrosis is the hallmark of virtually all progressive kidney diseases and strongly
correlates with the deterioration of kidney function. The renin-angiotensin-aldosterone …

Diabetes mellitus entails significant health problems worldwide. The pathogenesis of
diabetes is multifactorial, resulting from interactions of both genetic and environmental …