It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

The Ets family of transcription factors characterized by an evolutionarily-conserved DNA-
binding domain regulates expression of a variety of viral and cellular genes by binding to a …

Cancer development depends on the aberrant activation of signal transduction pathways
that control cell growth and survival and play important roles in normal embryonic …

The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

The Wnt pathway regulates cell fate, proliferation, and apoptosis, and defects in the pathway
play a key role in many cancers. Although Wnts act to stabilize β-catenin levels in the cytosol …

Many human cancers exhibit elevated prostaglandin (PG) levels due to upregulation of
cyclooxygenase-2 (COX-2), a key enzyme in eicosanoid biosynthesis. COX-2 over …

Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. Clinical and
molecular studies implicate human epidermal growth factor receptor 2 (HER2) in the …

Expression of cyclooxygenase-2 (COX-2) has been reported to be elevated in human
colorectal adenocarcinoma and other tumors, including those of breast, cervical, prostate …

Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of
human colorectal cancers. Loss of functional APC protein activates the Wnt signal …