Recent genomic and biological studies of neuroblastoma have shed light on the dramatic
heterogeneity in the clinical behaviour of this disease, which spans from spontaneous …

Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system.
However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the …

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated
neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Neuroblastoma is a childhood cancer that resembles developmental stages of the neural
crest. It is not established what developmental processes neuroblastoma cancer cells …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

MicroRNAs (miRNAs) are an emerging class of small non-coding RNAs implicated in a wide
variety of cellular processes. Research in this field is accelerating, and the growing number …

Neuroblastoma is the most common extracranial solid tumor and accounts for∼ 10% of
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …