Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander Effects In Vitro

WF Morgan - Radiation research, 2003 - meridian.allenpress.com
Morgan, W. Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-
Induced Genomic Instability and Bystander Effects In Vitro. Radiat. Res. 159, 567–580 …

Radiation-induced genomic instability and its implications for radiation carcinogenesis

L Huang, AR Snyder, WF Morgan - Oncogene, 2003 - nature.com
Radiation-induced genomic instability is characterized by an increased rate of genetic
alterations including cytogenetic rearrangements, mutations, gene amplifications …

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M Jinek, E Charpentier… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M Jinek, K Chylinski… - US Patent …, 2018 - Google Patents
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …

[PDF][PDF] Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells.

RD Johnson, M Jasin - The EMBO journal, 2000 - embopress.org
In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous
and nonhomologous mechanisms. By definition, homologous recombination requires a …

CRISPR-Cas component systems, methods and compositions for sequence manipulation

F Zhang, DO BIKARD, L Cong, DBT Cox, P Hsu… - 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49881125&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

CRISPR-related methods and compositions with governing gRNAS

F Zhang, D Palestrant, B Davidson, J Mata-Fink… - US Patent …, 2017 - Google Patents
US9834791B2 - CRISPR-related methods and compositions with governing gRNAS -
Google Patents US9834791B2 - CRISPR-related methods and compositions with …

Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications

F Zhang, RJ Platt, G Feng, Y Zhou - US Patent 11,041,173, 2021 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883289&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions foe cell death, chromosomal aberrations, mutations and …

G Obe, C Johannes, D Schulte-Frohlinde - Mutagenesis;(United Kingdom), 1992 - osti.gov
In this review we describe the chemical structures of end groups of DNA double strand break
(DSB) induced by ionizing radiation with low linear energy transfer (LET), by pancreatic …

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M Jinek, E Charpentier… - US Patent …, 2018 - Google Patents
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …