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Radiation-induced genomic instability is characterized by an increased rate of genetic alterations including cytogenetic rearrangements, mutations, gene amplifications …
JA Doudna, M Jinek, K Chylinski… - US Patent …, 2018 - Google Patents
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target …
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In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and nonhomologous mechanisms. By definition, homologous recombination requires a …
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In this review we describe the chemical structures of end groups of DNA double strand break (DSB) induced by ionizing radiation with low linear energy transfer (LET), by pancreatic …
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target …