Mitogen‐activated protein kinase (MAPK) pathways constitute a large modular network that
regulates a variety of physiological processes, such as cell growth, differentiation, and …

Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle soon after birth in
mammals. Although the extent to which adult cardiac myocytes are capable of cell cycle …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

Stem cell function is central for the maintenance of normal tissue homeostasis. Here we
show that deletion of p38α mitogen-activated protein (MAP) kinase in adult mice results in …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

Abstract Dual-specificity phosphatase 6 (DUSP6) serves a specific and conserved function
on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). We …

Rationale: The Hippo pathway plays an important role in determining organ size through
regulation of cell proliferation and apoptosis. Hippo inactivation and consequent activation …

Background—Specific transcription factors (TFs) modulate cardiac gene expression in
murine models of heart failure, but their relevance in human subjects remains untested. We …

Abstract Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting
enzyme of heme degradation. The HO products carbon monoxide and bilirubin not only …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …