Calcium signaling regulates autophagy and apoptosis

P Sukumaran, V Nascimento Da Conceicao, Y Sun… - Cells, 2021 - mdpi.com
Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Molecular regulation of autophagy machinery by mTOR‐dependent and‐independent pathways

MAA Al‐Bari, P Xu - Annals of the New York Academy of …, 2020 - Wiley Online Library
Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis

S Kan, M Duan, Y Liu, C Wang, J Xie - Cartilage, 2021 - journals.sagepub.com
Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies

S Mareedu, ED Million, D Duan, GJ Babu - Frontiers in physiology, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

Mitochondria-associated ER membranes–the origin site of autophagy

M Yang, C Li, S Yang, Y Xiao, X Xiong… - Frontiers in cell and …, 2020 - frontiersin.org
Autophagy is a process of intracellular self-recycling and degradation that plays an
important role in maintaining cell homeostasis. However, the molecular mechanism of …

Ion channels of the sarcolemma and intracellular organelles in Duchenne muscular dystrophy: a role in the dysregulation of ion homeostasis and a possible target for …

MV Dubinin, KN Belosludtsev - International Journal of Molecular …, 2023 - mdpi.com
Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein
and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells …

A gating mutation in ryanodine receptor type 2 rescues phenotypes of Alzheimer's disease mouse models by upregulating neuronal autophagy

H Zhang, C Knight, SRW Chen… - Journal of …, 2023 - Soc Neuroscience
It is well established that ryanodine receptors (RyanRs) are overactive in Alzheimer's
disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for …

[HTML][HTML] Duchenne muscular dystrophy is associated with the inhibition of calcium uniport in mitochondria and an increased sensitivity of the organelles to the calcium …

MV Dubinin, EY Talanov, KS Tenkov… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Duchenne muscular dystrophy (DMD) is characterized by a pronounced and progressive
degradation of the structure of skeletal muscles, which decreases their strength and lowers …

The interplay of mitophagy and inflammation in Duchenne muscular dystrophy

AL Reid, MS Alexander - Life, 2021 - mdpi.com
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease caused by a
pathogenic disruption of the DYSTROPHIN gene that results in non-functional dystrophin …

[HTML][HTML] Mitochondrial destabilization in tendinopathy and potential therapeutic strategies

L Cheng, Q Zheng, K Qiu, X Chen, Z Yin - Journal of Orthopaedic …, 2024 - Elsevier
Tendinopathy is a prevalent aging-related disorder characterized by pain, swelling, and
impaired function, often resulting from micro-scarring and degeneration caused by overuse …