Exploiting the biosynthetic potential of type III polyketide synthases

YP Lim, MK Go, WS Yew - Molecules, 2016 - mdpi.com
Polyketides are structurally and functionally diverse secondary metabolites that are
biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies …

How structural subtleties lead to molecular diversity for the type III polyketide synthases

H Morita, CP Wong, I Abe - Journal of Biological Chemistry, 2019 - ASBMB
Type III polyketide synthases (PKSs) produce an incredibly diverse group of plant
specialized metabolites with medical importance despite their structural simplicity compared …

Improving key enzyme activity in phenylpropanoid pathway with a designed biosensor

D Xiong, S Lu, J Wu, C Liang, W Wang, W Wang… - Metabolic …, 2017 - Elsevier
Overexpressing key enzymes of biosynthetic pathways for overproduction of value-added
products usually imposes metabolic burdens on cells, which can be circumvented by …

Reshaping the 2‐Pyrone Synthase Active Site for Chemoselective Biosynthesis of Polyketides

Y Zhou, EN Mirts, S Yook, M Waugh… - Angewandte Chemie …, 2023 - Wiley Online Library
Engineering enzymes with novel reactivity and applying them in metabolic pathways to
produce valuable products are quite challenging due to the intrinsic complexity of metabolic …

Expanding the Chemical Palette of Industrial Microbes: Metabolic Engineering for Type III PKS‐Derived Polyketides

CM Palmer, HS Alper - Biotechnology Journal, 2019 - Wiley Online Library
Polyketides are a unique class of molecules with attractive bioactive and chemical
properties. As a result, biorenewable production is being explored with these molecules as …

Biosynthetic origins of unusual cannabimimetic phytocannabinoids in Cannabis sativa L: a review

MT Welling, MA Deseo, A Bacic, MS Doblin - Phytochemistry, 2022 - Elsevier
Plants of Cannabis sativa L.(Cannabaceae) produce an array of more than 160
isoprenylated resorcinyl polyketides, commonly referred to as phytocannabinoids. These …

Multi-dimensional" projection"-the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch

Y Han, Z Hou, X Zhang, Q He, Z Liang - Environmental and Experimental …, 2022 - Elsevier
Triterpenoids and flavonoids from licorice (Glycyrrhiza uralensis Fisch.) are known to have a
wide range of applications in the pharmaceutical, skin care, and food industries. The effects …

Biosynthesis of nature-inspired unnatural cannabinoids

KJH Lim, YP Lim, YD Hartono, MK Go, H Fan, WS Yew - Molecules, 2021 - mdpi.com
Natural products make up a large proportion of medicine available today. Cannabinoids
from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a …

An atypical Acyl‐CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold

M Zheng, J Zhang, W Zhang, L Yang, X Yan… - Angewandte …, 2022 - Wiley Online Library
Acyl‐CoAs are key precursors of primary and secondary metabolism. Their efficient
biosynthesis is often impeded by the limited substrate specificity and low in vivo activity of …

Genome-Wide Mining of the Tandem Duplicated Type III Polyketide Synthases and Their Expression, Structure Analysis of Senna tora

Z Cai, X Zhao, C Zhou, T Fang, G Liu, J Luo - International Journal of …, 2023 - mdpi.com
Senna tora is one of the homologous crops used as a medicinal food containing an
abundance of anthraquinones. Type III polyketide synthases (PKSs) are key enzymes that …