The ins-and-outs of exosome biogenesis, secretion, and internalization

SB Arya, SP Collie, CA Parent - Trends in cell biology, 2024 - cell.com
Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of
multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion

DA Liu, K Tao, B Wu, Z Yu, M Szczepaniak… - Nature …, 2023 - nature.com
Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs)
dock and fuse with the plasma membrane. However, MVEs are also known to fuse with …

[HTML][HTML] A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

J Li, Y Zhang, PY Dong, GM Yang… - Biomedicine & …, 2023 - Elsevier
All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer

YJ Lee, KJ Shin, YC Chae - Experimental & Molecular Medicine, 2024 - nature.com
Extracellular vesicles (EVs), including exosomes, are increasingly recognized as potent
mediators of intercellular communication due to their capacity to transport a diverse array of …

The Rubicon–WIPI axis regulates exosome biogenesis during ageing

K Yanagawa, A Kuma, M Hamasaki, S Kita… - Nature Cell …, 2024 - nature.com
Cells release intraluminal vesicles in multivesicular bodies as exosomes to communicate
with other cells. Although recent studies suggest an intimate link between exosome …

The role of extracellular vesicles in the pathogenesis of hematological malignancies: interaction with tumor microenvironment; a potential biomarker and targeted …

K Das, T Mukherjee, P Shankar - Biomolecules, 2023 - mdpi.com
The tumor microenvironment (TME) plays an important role in the development and
progression of hematological malignancies. In recent years, studies have focused on …

Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151

Y Lin, H Zheng, L Jia, Y Luo, D Zhang… - Journal of …, 2024 - Wiley Online Library
Heterogeneous extracellular vesicles (EVs) from various types of tumours are
acknowledged for inducing the formation of pre‐metastatic “niches” in draining lymph nodes …

LAMTOR1 decreased exosomal PD-L1 to enhance immunotherapy efficacy in non-small cell lung cancer

B Wu, X Huang, X Shi, M Jiang, H Liu, L Zhao - Molecular Cancer, 2024 - Springer
Great progress has been made in utilizing immune checkpoint blockade (ICB) for the
treatment of non-small-cell lung cancer (NSCLC). Therapies targeting programmed cell …

[HTML][HTML] Function and biomedical implications of exosomal microRNAs delivered by parenchymal and nonparenchymal cells in hepatocellular carcinoma

HC Wang, WX Yin, M Jiang, JY Han… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Small extracellular vesicles (exosomes) are important components of the tumor
microenvironment. They are small membrane-bound vesicles derived from almost all cell …