Advanced crystallisation methods for small organic molecules

JP Metherall, RC Carroll, SJ Coles, MJ Hall… - Chemical Society …, 2023 - pubs.rsc.org
Molecular materials based on small organic molecules often require advanced structural
analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In …

Current trends and advancements in crystallization and single-crystal structural analysis of small molecules

Y Xiao, C Wu, L Zhou, P Commins, L Li… - Coordination Chemistry …, 2024 - Elsevier
The advancement of single-crystal structural analysis has emerged as a pivotal technology
surpassing spectroscopic methods in revealing the intricate structural details of organic …

Discovery of anticancer agents of diverse natural origin

LN Aldrich, JE Burdette… - Journal of natural …, 2022 - ACS Publications
Research progress from mainly over the last five years is described for a multidisciplinary
collaborative program project directed toward the discovery of potential anticancer agents …

Embellicines CE: Macrocyclic Alkaloids with a Cyclopenta[b]fluorene Ring System from the Fungus Sarocladium sp.

ZY Al Subeh, L Flores-Bocanegra… - Journal of Natural …, 2023 - ACS Publications
Macrocyclic alkaloids with a cyclopenta [b] fluorene ring system are a relatively young
structural class of fungal metabolites, with the first members reported in 2013. Bioassay …

Naturally occurring partially reduced perylenequinones from fungi

R Geris, MA Pinho, EF Boffo… - Journal of Natural …, 2022 - ACS Publications
This Review provides a critical analysis of the literature covering the naturally occurring
partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can …

Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol

HE Straker, L McMillan, L Mardiana, GR Hebberd… - …, 2023 - pubs.rsc.org
Cannabidiol (CBD) is a naturally occurring phytocannabinoid, approved for use in the US
and other countries for the treatment of seizures associated with Dravet syndrome, Lennox …

Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster

NJ Ayon, CE Earp, R Gupta, FA Butun, AE Clements… - Metabolomics, 2024 - Springer
Introduction Fungi biosynthesize chemically diverse secondary metabolites with a wide
range of biological activities. Natural product scientists have increasingly turned towards …

One-step synthesis of novel phaeosphaerin derivatives for photocytotoxicity

J Xie, G Song, F Lv - Dyes and Pigments, 2024 - Elsevier
Natural products have good potential in the photodynamic therapy (PDT) of clinical diseases
such as cancer. As a photosensitizer with excellent properties, natural hypocrellins have …

[PDF][PDF] High-throughput nanoscale crystallization of dihydropyridine active pharmaceutical ingredients

JP Metherall, PA Corner, JF McCabe… - … Section B: Structural …, 2024 - journals.iucr.org
Single-crystal X-ray diffraction analysis of small molecule active pharmaceutical ingredients
is a key technique in the confirmation of molecular connectivity, including absolute …

Polymorphic ROYalty: The 14th ROY Polymorph Discovered via High-Throughput Crystallization

J Weatherston, M Probert, MJ Hall - 2024 - chemrxiv.org
Polymorphism, when a substance can exist in more than one crystalline form yet return to
the same liquid or solution phase, is characterized by differences in packing or molecular …