Conspectus Stereodefined aliphatic heterocycles are one of the fundamental structural
motifs observed in natural products and biologically active compounds. Various strategies …

Microreactor technology has proved to be an important technique in organic synthesis,
especially when organometallic compounds are used, because it allows running rapid …

Flow chemistry is a continually emerging and ever-growing area of synthetic organic
chemistry. It provides an orthogonal approach to traditional batch chemistry, oftentimes …

Oxadiazoles are a common motif in pharmaceutical chemistry, but few convenient methods
for their modification exist. A fast, convenient, high yielding and general α‐substitution of 1 …

Flow microreactors enabled the successful generation of various functional alkyllithiums
containing electrophilic functional groups, as well as the use of these alkyllithiums in …

Tetrazoles play a prominent role in medicinal chemistry due to their role as carboxylate
bioisosteres but have largely been overlooked as C–H functionalisation substrates. We …

Aryl and heteroaryl rings are omnipresent in small molecule drugs, and examples bearing
multiple substitutions at benzylic positions are ubiquitous across a range of pharmaceutical …

Chirality is one of the most important types of steric information in nature. In addition to
central chirality, axial chirality has been catching more and more attention from scientists …

The development of suitable reaction conditions for the rapid “high” temperature lithiation-
trapping of N-Boc pyrrolidine under batch and flow conditions is described. For optimisation …

An asymmetric organocatalytic nucleophilic aromatic substitution reaction of azlactones with
electron-deficient aryls was established. A variety of α-aryl α-alkyl α-amino acid esters and …