Breast cancer is a heterogeneous disease, comprising multiple entities associated with
distinctive histological and biological features, clinical presentations and behaviours and …

Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …

Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and
molecules secreted by CAFs play an important role in tumor progression and metastasis …

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

Despite advances in the treatment of patients with early and metastatic breast cancer,
mortality remains high due to intrinsic or acquired resistance to therapy. Increased …

The hypoxic tumor microenvironment has been implicated in immune escape, but the
underlying mechanism remains elusive. Using an in vitro culture system modeling human T …

Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …

The analysis of the causes that have given rise to a change in tendency in the incidence and
mortality rates of breast cancer in the last few decades generates important revelations …

Triple-negative breast cancer (TNBC) is more aggressive and difficult to treat using
conventional bulk chemotherapy that is often associated with increased toxicity and side …

Background Breast cancer is one of the most common malignancies and the major cause of
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …