Mitophagy in human health, ageing and disease

A Picca, J Faitg, J Auwerx, L Ferrucci, D D'Amico - Nature Metabolism, 2023 - nature.com
Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Defective autophagy and mitophagy in aging and Alzheimer's disease

M Tran, PH Reddy - Frontiers in neuroscience, 2021 - frontiersin.org
Aging is the time-dependent process that all living organisms go through characterized by
declining physiological function due to alterations in metabolic and molecular pathways …

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

[HTML][HTML] Faces of cellular senescence in skin aging

CY Ho, O Dreesen - Mechanisms of Ageing and Development, 2021 - Elsevier
The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

[HTML][HTML] PGAM5: A crucial role in mitochondrial dynamics and programmed cell death

M Cheng, N Lin, D Dong, J Ma, J Su, L Sun - European journal of cell …, 2021 - Elsevier
In response to mitochondrial damage, mitochondria activate mitochondrial dynamics to
maintain normal functions, and an imbalance in mitochondrial dynamics triggers multiple …

Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

DNA damage and mitochondria in cancer and aging

J Patel, BA Baptiste, E Kim, M Hussain… - …, 2020 - academic.oup.com
Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

PINK1: The guard of mitochondria

N Wang, P Zhu, R Huang, C Wang, L Sun, B Lan, Y He… - Life sciences, 2020 - Elsevier
PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has
been highlighted for its role in early-onset Parkinson's disease. In recent years, an …

Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

A Irazoki, M Martinez‐Vicente, P Aparicio, C Aris… - Aging …, 2022 - Wiley Online Library
Sarcopenia is one of the main factors contributing to the disability of aged people. Among
the possible molecular determinants of sarcopenia, increasing evidences suggest that …

Antioxidant peptides from collagen hydrolysate of redlip croaker (Pseudosciaena polyactis) scales: Preparation, characterization, and cytoprotective effects on H2O2 …

WY Wang, YQ Zhao, GX Zhao, CF Chi, B Wang - Marine drugs, 2020 - mdpi.com
Bioactive peptides from fish collagens with antioxidant properties have become a topic of
great interest for health, food, and processing/preservation industries. To explore the high …