Shedding light on antisocial behavior through genetically informed research

P Pezzoli, EJ McCrory, E Viding - Annual Review of Psychology, 2024 - annualreviews.org
Antisocial behavior (ASB) refers to a set of behaviors that violate social norms and disregard
the well-being and rights of others. In this review, we synthesize evidence from studies using …

What doesn't kill us makes us stronger: insights from neuroscience studies and molecular genetics

Y Gan, H Huang, X Wu, M Meng - Current Opinion in Behavioral Sciences, 2024 - Elsevier
Highlights•Neural mechanisms underlying stress and resilience are discussed.•Genetic
factors may partially determine why only some individuals develop resilience.•Machine …

Why mental disorders are brain disorders. And why they are not: ADHD and the challenges of heterogeneity and reification

S Schleim - Frontiers in Psychiatry, 2022 - frontiersin.org
Scientific attempts to identify biomarkers to reliably diagnose mental disorders have thus far
been unsuccessful. This has inspired the Research Domain Criteria (RDoC) approach …

[HTML][HTML] A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores

D Serpico - Studies in History and Philosophy of Science, 2023 - Elsevier
Research in pharmacogenomics and precision medicine has recently introduced the
concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many …

[HTML][HTML] Monozygotic twins discordant for depression: An extended network comparison of depressive symptoms, cognitive functions and daily activities

M Moron, J Mengel-From, M Semkovska - Journal of Psychiatric Research, 2024 - Elsevier
Monozygotic twins share the same genotype; however, they can be phenotypically
discordant on various traits. Studying discordant monozygotic twins allows the investigation …

MicroRNA and MicroRNA-Target variants associated with autism spectrum disorder and related disorders

A Wong, A Zhou, X Cao, V Mahaganapathy, M Azaro… - Genes, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder with a
complex and heterogeneous genetic etiology. MicroRNA (miRNA), a class of small non …

Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders

S Yokoyama - Frontiers in Immunology, 2023 - frontiersin.org
Bone marrow stromal cell antigen-1 (BST-1/CD157) is an immune/inflammatory regulator
that functions as both nicotinamide adenine dinucleotide-metabolizing ectoenzyme and cell …

[图书][B] Mental health and enhancement: substance use and its social implications

S Schleim - 2023 - library.oapen.org
This book takes the reader from basic questions like “What is health?” and “What is a
psychiatric disorder?”, into the midst of people's present mental health and enhancement …

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens

R Cocoș, BO Popescu - Human Genomics, 2024 - Springer
Neurodegenerative diseases present complex genetic architectures, reflecting a continuum
from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data …

Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response

D Serpico, M Maziarz - European Journal for Philosophy of Science, 2023 - Springer
Heterogeneous treatment effects represent a major issue for medicine as they undermine
reliable inference and clinical decision-making. To overcome the issue, the current vision of …