In recent years, nanocrystal technology has been extensively investigated. Due to the
submicron particle size and unique physicochemical properties of nanocrystals, they …

Abstract Adopting the Quality by Design (QbD) approach in the drug development process
has transformed from “nice-to-do” into a crucial and required part of the development …

Drug nanocrystals have been used for a wide range of drug delivery platforms in the
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …

Wet-operated stirred media mills are commonly used in the field of fine and ultra-fine
grinding. Depending on the application, there are different mill geometries and mill …

Although heat is generated during the wet stirred media milling of drug suspensions, leading
to notable temperature rise, a comprehensive analysis of heat generation does not exist …

Oil-in-water emulsions were proposed to produce retinoic acid (RA)-loaded biopolymer-
based delivery systems applying spray-drying technology. They were characterized …

In this study, we developed ticagrelor-dispersed nanosuspension (TCG-NSP) to enhance
the dissolution and oral bioavailability of ticagrelor (TCG) through a statistical design …

Spray-dried pectin microparticles can potentially improve the oral bioavailability of peptides
by virtue of their mucoadhesion. However, developing such formulations with desirable …

Nanocrystal drug formulation involves several critical manufacturing procedures that result
in complex structures to improve drug solubility, dissolution, bioavailability, and …

The present study was conducted to harness spray drying technology as a novel method of
producing Ciprofloxacin nanocrystals inside liposomes (CNL) for inhalation delivery …