The chemical and pharmacological properties of mitragynine and its diastereomers: an insight review

T Karunakaran, KZ Ngew, AAD Zailan… - Frontiers in …, 2022 - frontiersin.org
Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a
psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to …

Clinical Implications of Kratom (Mitragyna speciosa) Use: a Literature Review

E Prevete, KPC Kuypers, EL Theunissen… - Current Addiction …, 2023 - Springer
Abstract Purpose of Review This work aims to provide an up-to-date review of the preclinical
and clinical scientific literature on the therapeutic value of kratom to better understand the …

[HTML][HTML] Antidiabetic and antioxidant activities of Mitragyna speciosa (kratom) leaf extract in type 2 diabetic rats

P Zhang, W Wei, X Zhang, C Wen… - Biomedicine & …, 2023 - Elsevier
Mitragyna speciosa is a medicinal plant with a reputation for treating pains, diabetes as well
as increasing energy and sexual desires. However, there is no scientific evidence to validate …

The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa Korth.): A Comprehensive Review

MFI Leong Bin Abdullah, D Singh - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: Kratom or Mitragyna speciosa (Korth.) has received overwhelming attention
recently due to its alleged pain-relieving effects. Despite its potential therapeutic value …

Kratom abuse potential 2021: an updated eight factor analysis

JE Henningfield, DW Wang, MA Huestis - Frontiers in Pharmacology, 2022 - frontiersin.org
Drugs are regulated in the United States (US) by the Controlled Substances Act (CSA) if
assessment of their abuse potential, including public health risks, show such control is …

A review on Mitragyna speciosa (Rubiaceae) as a prominent medicinal plant based on ethnobotany, phytochemistry and pharmacological activities

T Begum, MH Arzmi, A Khatib, ABMH Uddin… - Natural Product …, 2024 - Taylor & Francis
Mitragyna speciosa Korth (kratom) is a tropical indigenous tree of Southeast Asia. It is
commonly consumed by the people due to its various pharmacological properties. The …

[HTML][HTML] Effects of mitragynine on viability, proliferation, and migration of C6 rat glioma, SH-SY5Y human neuroblastoma, and HT22 immortalized mouse hippocampal …

K Viwatpinyo, S Mukda, S Warinhomhoun - Biomedicine & …, 2023 - Elsevier
Mitragynine (MG) is an indole alkaloid found in the extract of Mitragyna speciosa Korth
native to Southeast Asia. Although MG is known for its pain-relieving and psychoactive …

Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats

AN Zul Aznal, NA Mohamad Nor Hazalin… - Frontiers in …, 2022 - frontiersin.org
Adolescence is a critical developmental period during which exposure to psychoactive
substances like kratom (Mitragyna speciosa) can cause long-lasting deleterious effects …

Examining the psychoactive differences between kratom strains

G Huisman, M Menke, O Grundmann… - International journal of …, 2023 - mdpi.com
Kratom (Mitragyna speciosa) is a Southeast Asian plant containing various alkaloids that
induce pharmacological effects in humans. In Western countries, online vendors sell a …

Sustainable approaches for the study of alkaloids from plants using supercritical fluid-based processes

J Pavón-Pérez, A Vallejos-Almirall, C Agurto-Muñoz… - Green …, 2022 - pubs.rsc.org
Plant alkaloids are natural secondary metabolites that have attracted great interest in the
development of drugs for therapeutic applications due to their diverse bioactivities. For the …