Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

pH‐sensitive polymers: Classification and some fine potential applications

F Ofridam, M Tarhini, N Lebaz… - Polymers for …, 2021 - Wiley Online Library
Stimuli‐responsive materials in general and pH‐responsive polymers in particular have
gained increasing interest during the last two decades. Their unique properties, which arise …

Block copolymer nanostructures

T Smart, H Lomas, M Massignani, MV Flores-Merino… - Nano Today, 2008 - Elsevier
One of the most important classes of synthetic systems for creating self-assembled
nanostructures is amphiphilic block copolymers. By controlling the architecture of individual …

Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications

A Harada, K Kataoka - Progress in polymer science, 2006 - Elsevier
Multimolecular assemblies of block copolymers have received considerable attention from
both fundamental and applied standpoints. These assemblies are formed in selective …

Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems

J Sitterberg, A Özcetin, C Ehrhardt… - European Journal of …, 2010 - Elsevier
The introduction of atomic force microscopy (AFM) techniques has revolutionised our ability
to characterise colloidal objects. AFM allows the visualisation of samples with sub …

Zwitterionic drug nanocarriers: A biomimetic strategy for drug delivery

Q Jin, Y Chen, Y Wang, J Ji - Colloids and Surfaces B: Biointerfaces, 2014 - Elsevier
Nanomaterials self-assembled from amphiphilic functional copolymers have emerged as
safe and efficient nanocarriers for delivery of therapeutics. Surface engineering of the …

Polymer vectors via controlled/living radical polymerization for gene delivery

FJ Xu, WT Yang - Progress in Polymer Science, 2011 - Elsevier
The design of efficient gene delivery vectors is a challenging task in gene therapy. Recent
progress in living/controlled radical polymerizations (LRPs), in particular atom transfer …

Protein adsorption and cell adhesion on cationic, neutral, and anionic 2-methacryloyloxyethyl phosphorylcholine copolymer surfaces

Y Xu, M Takai, K Ishihara - Biomaterials, 2009 - Elsevier
Protein adsorption and cell adhesion on cationic, neutral, and anionic water-soluble 2-
methacryloyloxyethyl phosphorylcholine (MPC) copolymer surfaces were compared. These …

Synthesis and characterization of biocompatible, thermoresponsive ABC and ABA triblock copolymer gelators

C Li, NJ Buurma, I Haq, C Turner, SP Armes… - Langmuir, 2005 - ACS Publications
The synthesis of doubly thermoresponsive PPO− PMPC− PNIPAM triblock copolymer
gelators by atom transfer radical polymerization using a PPO-based macroinitiator is …

Enhanced gene transfection and serum stability of polyplexes by PDMAEMA-polysulfobetaine diblock copolymers

F Dai, W Liu - Biomaterials, 2011 - Elsevier
Polyethylene glycol or phosphorylcholine is often introduced into polycationic non-viral
vectors to inhibit the non-specific protein adsorption. However the ability of vectors to …