Supramolecular gels–a panorama of low-molecular-weight gelators from ancient origins to next-generation technologies

DK Smith - Soft Matter, 2024 - pubs.rsc.org
Supramolecular gels, self-assembled from low-molecular-weight gelators (LMWGs), have a
long history and a bright future. This review provides an overview of these materials, from …

Recently developed carbohydrate based gelators and their applications

J Morris, J Bietsch, K Bashaw, G Wang - Gels, 2021 - mdpi.com
Carbohydrate based low molecular weight gelators have been an intense subject of study
over the past decade. The self-assembling systems built from natural products have high …

Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable

H Wu, X Wang, G Wang, G Yuan, W Jia… - Advanced …, 2024 - Wiley Online Library
Over the decades, the management of osteochondral lesions remains a significant yet
unmet medical challenge without curative solutions to date. Owing to the complex nature of …

Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials

MA Ramin, L Latxague, KR Sindhu, O Chassande… - Biomaterials, 2017 - Elsevier
There is a critical need for soft materials in the field of regenerative medicine and tissue
engineering. However, designing injectable hydrogel scaffolds encompassing both …

Spatial and temporal diffusion-control of dynamic multi-domain self-assembled gels

L Schlichter, CC Piras, DK Smith - Chemical Science, 2021 - pubs.rsc.org
The dynamic assembly of a pH-responsive low-molecular-weight gelator (LMWG) within the
pre-formed matrix of a second LMWG has been achieved via diffusion of an acid from a …

A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn (ii) phthalocyanine tetrasulfonic acid for combined chemo …

L Xu, M Zhao, Y Yang, Y Liang, C Sun… - Journal of Materials …, 2017 - pubs.rsc.org
Low molecular weight gels (LMWGs) have significant advantages in drug delivery such as
high drug loading capacity, in situ delivery of drug to the lesion site, sustaining drug release …

Controlled domain gels with a wide stiffness gradient simultaneously promote bone regeneration and suppress tumor recurrence through DAPK activity

Y Wang, J Zhang, X Shu, F Wu, J He - Chemical Engineering Journal, 2024 - Elsevier
The reconstruction of bone defects following bone tumor resection pose significant
challenges, including high risks for tumor recurrence. To address these challenges, we …

Combining gellan gum with a functional low-molecular-weight gelator to assemble stiff shaped hybrid hydrogels for stem cell growth

CC Piras, PG Genever, DK Smith - Materials Advances, 2022 - pubs.rsc.org
We report hybrid hydrogels that combine gellan gum (GG) polymer gelator (PG) with a low-
molecular weight gelator (LMWG) based on 1, 3: 2, 4-dibenzylidene sorbitol (DBS). We …

Controlled domain gels with a biomimetic gradient environment for osteochondral tissue regeneration

N Zhang, Y Wang, J Zhang, J Guo, J He - Acta Biomaterialia, 2021 - Elsevier
In order to repair an osteochondral defect, it is critical to advance a bi-lineage constructive
scaffold with gradient transition. In this study, we developed a simple and straightforward …

Commercially Relevant Orthogonal Multi‐Component Supramolecular Hydrogels for Programmed Cell Growth

VMP Vieira, AC Lima, M de Jong… - Chemistry–A European …, 2018 - Wiley Online Library
This study reports the ability of synthetically simple, commercially viable sugar‐derived 1, 3:
2, 4‐dibenzylidenesorbitol‐4′, 4 “‐diacylhydrazide (DBS‐CONHNH2) to support cell …