Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

This review explores the concept of synergy in pharmacology, emphasizing its importance in
optimizing treatment outcomes through the combination of drugs with different mechanisms …

In this communication, we introduce a general framework and discussion on the role of
models and the modeling process in the field of biosciences. The objective is to sum up the …

Originally implicated in the regulation of survival, proliferation and differentiation of
haematopoietic cells, the JAK-STAT pathway has also been linked to developmental …

Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share
a frequent constitutive activation of JAK (Janus kinase)/STAT signaling pathway. Because of …

In this work we present a general (mono and multiobjective) optimization framework for the
technological improvement of biochemical systems. The starting point of the method is a …

The erythropoietin (Epo) receptor (EpoR) is expressed in the brain and was shown to have
neuroprotective effects against brain damage in animal models. A recent study indicated that …

MicroRNAs (miRNAs) are a family of small regulatory RNAs whose function is to regulate the
activity and stability of specific messenger RNA targets through posttranscriptional …

This book focusing on the immunopathology of cancers is published as part of the three-
volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically …

In the near future, computational tools and methods based on the mathematical modeling of
biomedically relevant networks and pathways will be necessary for the design of therapeutic …