Treat-to-target in pediatric rheumatic diseases
S Rosina, AI Rebollo-Giménez, A Consolaro… - Current Rheumatology …, 2023 - Springer
Abstract Purpose of Review To summarize the current evidence on the adoption of the treat-
to-target (T2T) strategy in pediatric rheumatic diseases (PRD). Recent Findings The recent …
to-target (T2T) strategy in pediatric rheumatic diseases (PRD). Recent Findings The recent …
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
A Aggarwal, TAP Fernandes, A Migowa… - Current Allergy and …, 2024 - Springer
Abstract Purpose of Review Childhood-onset systemic lupus erythematosus (cSLE) is a
severe and potentially life-threatening chronic autoimmune disease. cSLE is more …
severe and potentially life-threatening chronic autoimmune disease. cSLE is more …
Evaluation of belimumab in treatment of Chinese childhood-onset systemic lupus erythematosus: a prospective analysis from a multicentre study
L Wang, X Liang, Z Cao, D Wang, Y Luo, Y Feng… - …, 2024 - academic.oup.com
Objective The aim of this study is to identify whether low lupus disease activity status
(LLDAS) and clinical remission (CR) of belimumab plus standard of care (SoC) therapy are …
(LLDAS) and clinical remission (CR) of belimumab plus standard of care (SoC) therapy are …
Active implementation of low disease activity state as a treatment endpoint in childhood-onset systemic lupus erythematosus in routine practice is both feasible and …
R Gotch, Y Ahmed, R Wilson, E Hawkins… - Clinical Rheumatology, 2024 - Springer
Introduction Treat-to-target (T2T) strategies aim to facilitate tight disease control to improve
outcomes. No previous studies evaluated prospectively the feasibility and impact of the T2T …
outcomes. No previous studies evaluated prospectively the feasibility and impact of the T2T …
Contributors to organ damage in childhood lupus: corticosteroid use and disease activity
M Hanif, C Sarker, E Al-Abadi, K Armon, K Bailey… - …, 2024 - academic.oup.com
Objectives Awareness of paediatric-specific predictors of damage in childhood lupus is
needed to inform mitigation measures. The objective of this study was to ascertain how …
needed to inform mitigation measures. The objective of this study was to ascertain how …
[HTML][HTML] Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
EMD Smith, A Aggarwal, J Ainsworth, E Al-Abadi… - Clinical …, 2024 - Elsevier
Objective To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-
to-target (T2T) trials, observational studies, and clinical practice. Methods The cSLE …
to-target (T2T) trials, observational studies, and clinical practice. Methods The cSLE …
Long-term outcomes and predictive factors of achieving low disease activity status in childhood systemic lupus erythematosus: a Chinese bicentric retrospective …
XX Yu, J Deng, QX Chen, SY Qiu, CH Jiang… - Frontiers in …, 2024 - frontiersin.org
Background This study aims to explore the clinical value of low disease activity state (LDAS)
in the treat-to-target strategy of pediatric systemic lupus erythematosus (pSLE) and find the …
in the treat-to-target strategy of pediatric systemic lupus erythematosus (pSLE) and find the …
Impact of serological activity on flare following clinically inactive disease and remission in childhood-onset systemic lupus erythematosus
Objectives The objectives of this study were to assess the association between serological
activity (SA) and clinical inactivity in SLE and to investigate whether SA predicts flare after …
activity (SA) and clinical inactivity in SLE and to investigate whether SA predicts flare after …
Updates in the care and management of children and adolescents with systemic lupus erythematosus
Current studies highlighted the various facets of cSLE, epidemiology, clinical, laboratory,
classification criteria, adolescent issues, prognosis, surveillance, T2T approach and drug …
classification criteria, adolescent issues, prognosis, surveillance, T2T approach and drug …
[HTML][HTML] First validation of the childhood lupus low disease activity state (cLLDAS) definition in a real-life longitudinal cSLE cohort
SC Bergkamp, T Kanagasabapathy, MP Gruppen… - Clinical …, 2024 - Elsevier
Objectives To validate the childhood lupus low disease activity state (cLLDAS) definition in
cSLE by describing differences in time to reach first adult LLDAS (aLLDAS) versus cLLDAS …
cSLE by describing differences in time to reach first adult LLDAS (aLLDAS) versus cLLDAS …