Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of
56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990s when …

Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

Deficiency in BRCA-dependent DNA interstrand crosslink (ICL) repair is intimately
connected to breast cancer susceptibility and to the rare developmental syndrome Fanconi …

Many sequence variants in predisposition genes are of uncertain clinical significance, and
classification of these variants into high-or low-risk categories is an important problem in …

Background: BRCA1 and BRCA2 are the two major susceptibility genes involved in
hereditary breast cancer. This study was undertaken to provide reliable population-based …

Germline mutations in the BRCA1 tumor suppressor gene often result in a significant
increase in susceptibility to breast and ovarian cancers. Although the molecular basis of …

The BRCT repeats in BRCA1 are essential for its tumor suppressor activity and interact with
phosphorylated protein targets containing the sequence pSer-XX-Phe, where X indicates …

Genetic screening of the breast and ovarian cancer susceptibility gene BRCA1 has
uncovered a large number of variants of uncertain clinical significance. Here, we use …

Purpose Triple-negative breast cancers (TNBCs) are tumors with low or no expression of
estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 …

We screened index cases from 410 Spanish breast/ovarian cancer families and 214 patients
(19 of them males) with breast cancer for germ‐line mutations in the BRCA1 and BRCA2 …