The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …

Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …

Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …

Mucoadhesion, the state in which two materials, amongst which one is biological in nature,
adhere to each other for extended periods of time with the help of interfacial forces, provides …

In the past few years, an increasing number of in situ-forming systems have been reported in
the literature for various biomedical applications, including drug delivery, cell encapsulation …

Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on
stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract …

Highlights•Poloxamers-based in situ gels are potential vehicles for ocular drug
delivery.•Poloxamers possess reversible thermoresponsive gelling and mucoadhesive …

In this review, we describe the application of thermosensitive hydrogels composed of
poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid …

Drug delivery via the rectum is a useful alternative route of administration to the oral route for
patients who cannot swallow. Traditional rectal dosage forms have been historically used for …

The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …