A fast growing field, the study of infants at risk because of having an older sibling with autism
(ie infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier …

The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific
mRNA binding proteins that control translation in development, health, and disease. CPEB1 …

The late 1990s were banner years in molecular neuroscience; seminal studies
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …

Background & Aims Vascular endothelial growth factor (VEGF) regulates angiogenesis, yet
therapeutic strategies to disrupt VEGF signaling can interfere with physiologic angiogenesis …

Life history and behavioral traits are often difficult to discern from the fossil record, but
evolutionary rates of genes and their changes over time can be inferred from extant genomic …

Protein translation is crucial for fear extinction, a process vital for adaptive behavior and
mental health, yet the underlying cell-specific mechanisms remain elusive. Using a Tet-On …

While we have considerable understanding of the transcriptional networks controlling
mammalian cell differentiation, our knowledge of posttranscriptional regulatory events is …

Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting
synaptic modifications and consolidate memory. We investigated the role of the translational …

Expression of mitochondrial proton transporter uncoupling protein 1 (UCP 1) in brown
adipose tissue (BAT) is essential for mammalian thermogenesis. While human UCP 1 …

Mammalian oocyte development depends on the temporally controlled translation of
maternal transcripts, particularly in the coordination of meiotic and early embryonic …