Pyrazine and phenazine heterocycles: platforms for total synthesis and drug discovery

RW Huigens III, BR Brummel, S Tenneti, AT Garrison… - Molecules, 2022 - mdpi.com
There are numerous pyrazine and phenazine compounds that demonstrate biological
activities relevant to the treatment of disease. In this review, we discuss pyrazine and …

Design strategies and applications of novel functionalized phenazine derivatives: a review

YX Che, XN Qi, Q Lin, H Yao, WJ Qu, B Shi… - Journal of Materials …, 2022 - pubs.rsc.org
Phenazine derivatives have made significant progress owing to their favorable
photophysical and chemical properties in recent years. Nevertheless, only a few overviews …

Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry

H Lu, H Ye, M Zhang, Z Liu, H Zou, L You - Nature Communications, 2023 - nature.com
Phototriggered click and clip reactions can endow chemical processes with high
spatiotemporal resolution and sustainability, but are challenging with a limited scope. Herein …

Biosynthesis, regulation, and engineering of natural products from Lysobacter

H Yue, AL Miller, V Khetrapal, V Jayaseker… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was
classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for …

[HTML][HTML] Recent Advances in Phenazine Natural Products: Chemical Structures and Biological Activities

W Huang, Y Wan, S Zhang, C Wang, Z Zhang, H Su… - Molecules, 2024 - mdpi.com
Phenazine natural products are a class of colored nitrogen-containing heterocycles
produced by various microorganisms mainly originating from marine and terrestrial sources …

Design, synthesis, and antibacterial activity of N-(trifluoromethyl) phenyl substituted pyrazole derivatives

I Saleh, HR Kc, S Roy, MK Abugazleh, H Ali… - RSC Medicinal …, 2021 - pubs.rsc.org
Design and synthesis of N-(trifluoromethyl) phenyl substituted pyrazole derivatives and their
potency as antimicrobial agents are described. Several of these novel compounds are …

Modular synthetic routes to fluorine-containing halogenated phenazine and acridine agents that induce rapid iron starvation in methicillin-resistant Staphylococcus …

K Liu, M Brivio, T Xiao, VM Norwood IV… - ACS infectious …, 2022 - ACS Publications
During infection, bacteria use an arsenal of resistance mechanisms to negate antibiotic
therapies. In addition, pathogenic bacteria form surface-attached biofilms bearing enriched …

Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis

Y Yang, Y Lu, C Zhang, Q Guo, W Zhang… - Cellular and Molecular …, 2022 - Springer
Breast cancer stem cells (BCSCs) are positively correlated with the metastasis,
chemoresistance, and recurrence of breast cancer. However, there are still no drugs …

Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation

K Liu, T Xiao, H Yang, M Chen, Q Gao… - RSC Medicinal …, 2023 - pubs.rsc.org
It is of great importance to develop new strategies to combat antibiotic resistance. Our lab
has discovered halogenated phenazine (HP) analogues that are highly active against …

Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters

K Liu, Y Abouelhassan, Y Zhang, S Jin… - ACS infectious …, 2022 - ACS Publications
Bacterial biofilms are surface-attached communities of slow-or non-replicating cells
embedded within a protective matrix of biomolecules. Unlike free-floating planktonic …