Implantation involves an extensive cross talk between the trophoblast cells and the receptive
endometrium through embryonic as well as endometrial‐derived factors that regulate the …

The ubiquitously expressed phosphoinositide 3-kinase (PI3K) family of lipid kinases control
diverse cellular functions including cell survival, proliferation, metabolism and migration …

ABSTRACT A successful pregnancy depends on the intricate and timely interactions of
maternal and fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular …

Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation.
The hemochorial placenta facilitates the acquisition of maternal resources required for …

A series of cyclical events within the uterus are crucial for pregnancy establishment. These
include endometrial regeneration following menses, under the influence of estrogen …

Infertility is constantly increasing in Canada, where 16% of Canadian couples are
experiencing difficulty conceiving. It is thought that infertility can emanate from the …

The protein ezrin has been shown to enhance cancer cell motility and invasion leading to
malignant behaviours in solid tumours, but a similar regulatory function in the early …

Invasiveness is a common feature of trophoblast and tumors; however, while tumor invasion
is uncontrolled, trophoblast invasion is strictly regulated. Both trophoblast and tumor cells …

Failures in human extravillous trophoblast (EVT) development could be involved in the
pathogenesis of pregnancy diseases. However, the underlying mechanisms have been …

Extravillous trophoblast (EVT) invasion is an essential component of human placentation.
Poor EVT invasion is associated with obstetrical complications including preeclampsia …