AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

Historically understudied, cholesterol in the retina is receiving more attention now because
of genetic studies showing that several cholesterol-related genes are risk factors for age …

Purpose: Basal laminar deposit (BLamD) is a consistent finding in age-related macular
degeneration (AMD). We quantified BLamD thickness, appearance, and topography in eyes …

Abstract Age-Related Macular Degeneration (AMD) is a complex multifactorial disease
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a
major cause of vision loss. However, the mechanisms underlying their progression remain ill …

Purpose.: To seek pathways of retinal pigment epithelium (RPE) fate in age-related macular
degeneration via a morphology grading system; provide nomenclature, visualization targets …

One of the strongest susceptibility genes for age-related macular degeneration (AMD) is
complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved …

Mouse models are powerful tools for the study of ocular diseases. Alterations in the
morphology and function of the retinal pigment epithelium (RPE) are common features …

Purpose.: Oxidative stress in the RPE is widely accepted as a contributing factor to AMD. We
have previously shown that ribozyme-mediated reduction in the antioxidant enzyme …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …