[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

The emergence and epidemic characteristics of the highly mutated SARS‐CoV‐2 Omicron variant

D Tian, Y Sun, H Xu, Q Ye - Journal of medical virology, 2022 - Wiley Online Library
Recently, the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron
variant (B. 1.1. 529) was first identified in Botswana in November 2021. It was first reported …

Evaluation of waning of SARS-CoV-2 vaccine–induced immunity: a systematic review and meta-analysis

F Menegale, M Manica, A Zardini, G Guzzetta… - JAMA Network …, 2023 - jamanetwork.com
Importance Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19
are key to assess population levels of protection and future needs for booster doses to face …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

CJ Reynolds, C Pade, JM Gibbons, AD Otter, KM Lin… - Science, 2022 - science.org
The Omicron, or Pango lineage B. 1.1. 529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

Bivalent omicron BA. 1–adapted BNT162b2 booster in adults older than 55 years

P Winokur, J Gayed, D Fitz-Patrick… - … England Journal of …, 2023 - Mass Medical Soc
Background The emergence of immune-escape variants of severe acute respiratory
syndrome coronavirus 2 warrants the use of sequence-adapted vaccines to provide …

Resistance of Omicron subvariants BA. 2.75. 2, BA. 4.6, and BQ. 1.1 to neutralizing antibodies

D Planas, T Bruel, I Staropoli… - Nature …, 2023 - nature.com
Convergent evolution of SARS-CoV-2 Omicron BA. 2, BA. 4, and BA. 5 lineages has led to
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B. 1.1. 529) and delta (B. 1.617. 2) variants in England: a cohort …

T Nyberg, NM Ferguson, SG Nash, HH Webster… - The lancet, 2022 - thelancet.com
Background The omicron variant (B. 1.1. 529) of SARS-CoV-2 has demonstrated partial
vaccine escape and high transmissibility, with early studies indicating lower severity of …

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA. 5 Omicron variant in mice

SM Scheaffer, D Lee, B Whitener, B Ying, K Wu… - Nature medicine, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants

HF Tseng, BK Ackerson, Y Luo, LS Sy, CA Talarico… - Nature medicine, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B. 1.1. 529)
variant is highly transmissible with potential immune escape. We conducted a test-negative …