The entry of enveloped viruses into its host cells is a crucial step for the propagation of viral
infection. The envelope glycoprotein complex controls viral tropism and promotes the …

The spike glycoproteins of many enveloped viruses are proteolytically cleaved at the
carboxytermini of sequences containing the basic motif RXK/RR. Cleavage is often …

Intracellular proteolytic processing of human immunodeficiency virus envelope glycoprotein
precursor (gp160) is an essential step for virus infectivity. Northern blot analysis provided …

The fusion (F) glycoprotein of respiratory syncytial virus (RSV) is synthesized as a
nonfusogenic precursor protein (F0), which during its migration to the cell surface is …

Of the 37.9 million individuals infected with human immunodeficiency virus type 1 (HIV-1),
approximately 50% exhibit HIV-associated neurocognitive disorders (HAND). We and others …

The human immunodeficiency virus HIV envelope glycoprotein gp160 is synthesized as an
inactive precursor, which is processed into its fusiogenic form gp120/gp41 by host cell …

We present here the pulse and pulse–chase analysis of the biosynthesis of the envelope
glycoprotein gp160 and its intracellular processing by the subtilisin/kexin-like convertases …

The introduction of highly active antiretroviral therapy has led to a significant reduction in the
morbidity and mortality of acquired immunodeficiency syndrome patients. However, the …

Proteolytic activation of HIV-1 and HIV-2 envelope glycoprotein precursors (gp160 and
gp140, respectively) occurs at the carboxyl side of a consensus motif consisting of the highly …

Efforts to understand the molecular basis of human immunodeficiency virus (HIV) envelope
glycoprotein function have been hampered by the inability to generate sufficient quantities of …