Objective Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with
substantial patient and population burdens. A number of comorbid health problems occur in …

Background: Chronic insufficient sleep is a common finding in many pain-related and other
medical diseases and is frequently experienced in the general population. Prolonged …

Background Atopic dermatitis (AD) is associated with chronic itch, allergic disease and sleep
disturbance, all of which might increase the risk of attention deficit (hyperactivity) disorder …

Laboratory conditions in biobehavioral experiments are commonly assumed to be
'controlled', having little impact on the outcome. However, recent studies have illustrated that …

Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically,
the disease is noted to worsen in a circadian manner at night. Epidemiologic findings …

Circadian rhythmicity can be important in the pathophysiology, diagnosis, and treatment of
clinical disease. Due to the difficulties in conducting the necessary experimental work, it …

Pain control is one of the most important therapeutic priorities; nonetheless, inadequate pain
relief remains a significant health care issue. Thus, it is important to determine whether the …

Acta Derm Venereol 87 night may provide another plausible explanation for the nocturnal
exacerbation of pruritus (17). Itch has been reported to be aggravated by ambient heat (2) …

Circadian rhythms of physiology are the keys to health and fitness, as dysregulation, by
genetic mutations or environmental factors, increases disease risk and aggravates …

Circadian sleep/wake rhythms are synchronized to environmental light/dark cycles in a
process known as photoentrainment. We have previously shown that activation of β …