Obesity I: Overview and molecular and biochemical mechanisms

RH Lustig, D Collier, C Kassotis, TA Roepke… - Biochemical …, 2022 - Elsevier
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

The molecular details of cytokine signaling via the JAK/STAT pathway

R Morris, NJ Kershaw, JJ Babon - Protein Science, 2018 - Wiley Online Library
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells

SY Lee, JS Cheah, B Zhao, C Xu, H Roh, CK Kim… - Nature …, 2023 - nature.com
The incorporation of light-responsive domains into engineered proteins has enabled control
of protein localization, interactions and function with light. We integrated optogenetic control …

The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

F Seif, M Khoshmirsafa, H Aazami… - Cell communication and …, 2017 - Springer
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …

Leptin resistance: underlying mechanisms and diagnosis

O Gruzdeva, D Borodkina, E Uchasova… - … syndrome and obesity …, 2019 - Taylor & Francis
Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

The cellular and molecular bases of leptin and ghrelin resistance in obesity

H Cui, M López, K Rahmouni - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Leptin and the maintenance of elevated body weight

WW Pan, MG Myers Jr - Nature Reviews Neuroscience, 2018 - nature.com
Obesity represents the single most important risk factor for early disability and death in
developed societies, and the incidence of obesity remains at staggering levels. CNS …

Adipose tissue in obesity‐related inflammation and insulin resistance: cells, cytokines, and chemokines

K Makki, P Froguel, I Wolowczuk - … Scholarly Research Notices, 2013 - Wiley Online Library
Adipose tissue is a complex organ that comprises a wide range of cell types with diverse
energy storage, metabolic regulation, and neuroendocrine and immune functions. Because …

Leptin in inflammation and autoimmunity

A La Cava - Cytokine, 2017 - Elsevier
After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of …

A Ścibior, Ł Pietrzyk, Z Plewa, A Skiba - … of Trace Elements in Medicine and …, 2020 - Elsevier
Background Vanadium (V) is an element with a wide range of effects on the mammalian
organism. The ability of this metal to form organometallic compounds has contributed to the …