Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

Glucokinase–maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is
caused by heterozygous inactivating mutations in the GCK gene. GCK gene mutations are …

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of
disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of …

EARLY HISTORY—In the academic year 1949–1950, one of us (SSF), while a first-year
Fellow in Endocrinology and Metabolism at the University of Michigan (Jerome W. Conn …

Low birthweight is associated with insulin resistance, hypertension, coronary-artery disease,
and non-insulin-dependent diabetes (NIDDM). A suggested explanation for this association …

The intestinally derived hormone glucagon-like peptide 1 (GLP-1)(7-36 amide) has potent
effects on glucose-mediated insulin secretion, insulin gene expression, and β-cell growth …

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are incretin hormones secreted in response to meal ingestion, thereby enhancing …

Low birth weight and fetal thinness have been associated with non-insulin dependent
diabetes mellitus (NIDDM) and insulin resistance in childhood and adulthood 1, 2, 3, 4, 5, 6 …

Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or
relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to …

Abstract Aims/hypothesis C57BL/6J mice exhibit impaired glucose tolerance. The aims of
this study were to map the genetic loci underlying this phenotype, to further characterise the …