Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the
genome is carried out by the viral RNA-dependent RNA polymerase in the context of the …

RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

The recent research findings on influenza A virus (IAV) genome biology prompted us to
present a comprehensive overview of IAV genes, protein functions, and replication cycle …

Influenza polymerase uses unique mechanisms to synthesize capped and polyadenylated
mRNAs from the genomic viral RNA (vRNA) template, which is packaged inside …

The genome of influenza A virus (IAV) consists of eight unique viral RNA segments. This
genome organization allows genetic reassortment between co-infecting IAV strains …

Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of
triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian …

Influenza polymerase (FluPol) plays a key role in the viral infection cycle by transcribing and
replicating the viral genome. FluPol is a multifunctional, heterotrimeric enzyme with cap …

Negative and ambisense RNA viruses are the causative agents of important human
diseases such as influenza, measles, Lassa fever, and Ebola hemorrhagic fever. The viral …

Influenza virus genome encapsidation is essential for the formation of a helical viral
ribonucleoprotein (vRNP) complex composed of nucleoproteins (NP), the trimeric …

Emerging viruses impose global threats to animal and human populations and may bear
novel genes with limited homology to known sequences, necessitating the development of …