International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

J Hamann, G Aust, D Araç, FB Engel, C Formstone… - Pharmacological …, 2015 - ASPET
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Review of rodent models of attention deficit hyperactivity disorder

SL Regan, MT Williams, CV Vorhees - Neuroscience & Biobehavioral …, 2022 - Elsevier
Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder
that affects 8–12% of children and> 4% of adults. Environmental factors are believed to …

The tethered peptide activation mechanism of adhesion GPCRs

X Barros-Álvarez, RM Nwokonko, A Vizurraga… - Nature, 2022 - nature.com
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-
proteolysing extracellular regions that are involved in cell–cell and cell–extracellular matrix …

Molecular psychiatry of zebrafish

AM Stewart, JFP Ullmann, WHJ Norton, MO Parker… - Molecular …, 2015 - nature.com
Due to their well-characterized neural development and high genetic homology to
mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field …

[HTML][HTML] Attention-deficit/hyperactive disorder updates

M Kessi, H Duan, J Xiong, B Chen, F He… - Frontiers in molecular …, 2022 - frontiersin.org
Background Attention-deficit/hyperactive disorder (ADHD) is a neurodevelopmental disorder
that commonly occurs in children with a prevalence ranging from 3.4 to 7.2%. It profoundly …

Molecular genetic studies of ADHD and its candidate genes: a review

Z Li, S Chang, L Zhang, L Gao, J Wang - Psychiatry research, 2014 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset psychiatric
disorder with high heritability. In recent years, numerous molecular genetic studies have …

[HTML][HTML] Brain imaging genetics in ADHD and beyond–Mapping pathways from gene to disorder at different levels of complexity

M Klein, M Onnink, M van Donkelaar, T Wolfers… - Neuroscience & …, 2017 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent
neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as …

[HTML][HTML] The role of ADHD associated genes in neurodevelopment

C Dark, J Homman-Ludiye… - Developmental biology, 2018 - Elsevier
Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental
disorder of childhood. It is primarily characterised by high levels of activity, inattention, and …

[HTML][HTML] G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

TS Wong, G Li, S Li, W Gao, G Chen, S Gan… - … and Targeted Therapy, 2023 - nature.com
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Adhesion G protein–coupled receptors as drug targets

RH Purcell, RA Hall - Annual review of pharmacology and …, 2018 - annualreviews.org
The adhesion G protein–coupled receptors (aGPCRs) are an evolutionarily ancient family of
receptors that play key roles in many different physiological processes. These receptors are …