Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

Histone deacetylase (HDAC) inhibitors are an emerging class of promising novel anticancer
drugs. However, little is known which one of the 11 classical HDAC family members is the …

Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in
nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also …

Histone deacetylases (HDACs) are an emerging class of novel anti-cancer drug targets.
Recently, studies in adult cancers and in neuroblastoma have shown that individual HDAC …

Cholesterol is an essential component of the central nervous system and increasing
evidence suggests an association between brain cholesterol metabolism dysfunction and …

Valproic acid (VPA) has been used for epilepsy treatment since the 1970s. Recently, it was
demonstrated that it inhibits histone deacetylases (HDAC), modulates cell cycle, induces …

Abstract Background Histone deacetylase inhibitors (HDACi) are a new class of promising
anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low …

Multiple molecular resistance mechanisms reduce the efficiency of receptor tyrosine kinase
inhibitors such as gefitinib in non-small cell lung cancer (NSCLC). We previously …

Post-stroke dementia (PSD) is a common clinical disease and the central cholinergic circuits
are important to cognitive function. Icariin (ICA), a flavonoid isolated from Herba Epimedii …

The first known function of Ku70 is as a DNA repair factor in the nucleus. Using neuronal
neuroblastoma cells as a model, we have established that cytosolic Ku70 binds to the pro …