Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer

N Wang, JY Fang - Trends in Microbiology, 2023 - cell.com
Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The
dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC …

The oral–gut microbiome axis in health and disease

BJ Kunath, C De Rudder, CC Laczny… - Nature Reviews …, 2024 - nature.com
The human body hosts trillions of microorganisms throughout many diverse habitats with
different physico-chemical characteristics. Among them, the oral cavity and the gut harbour …

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

JL Galeano Niño, H Wu, KD LaCourse… - Nature, 2022 - nature.com
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment
across human cancer types,. Intratumoral host–microbiota studies have so far largely relied …

Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer

SS Jiang, YL Xie, XY Xiao, ZR Kang, XL Lin, L Zhang… - Cell host & …, 2023 - cell.com
Immune checkpoint blockade therapy with anti-PD-1 monoclonal antibody (mAb) is a
treatment for colorectal cancer (CRC). However, some patients remain unresponsive to PD …

The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota

KD LaCourse, M Zepeda-Rivera, AG Kempchinsky… - Cell Reports, 2022 - cell.com
Fusobacterium nucleatum (Fn) is a dominant bacterial species in colorectal cancer (CRC)
tissue that is associated with cancer progression and poorer patient prognosis. Following a …

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

M Zepeda-Rivera, SS Minot, H Bouzek, H Wu… - Nature, 2024 - nature.com
Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely
found in the lower gastrointestinal tract of healthy individuals, is enriched in human …

Fusobacterium nucleatum and cancer

T Alon‐Maimon, O Mandelboim… - Periodontology …, 2022 - Wiley Online Library
Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is
involved in the progression of an increasing number of tumors types. Thus far, the …

Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation

J Queen, F Shaikh, CL Sears - Nature Cancer, 2023 - nature.com
The intersection of the microbiota and cancer and the mechanisms that define these
interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here …

[HTML][HTML] High fat diet, gut microbiome and gastrointestinal cancer

Y Tong, H Gao, Q Qi, X Liu, J Li, J Gao, P Li, Y Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Gastrointestinal cancer is currently one of the main causes of cancer death, with a large
number of cases and a wide range of lesioned sites. A high fat diet, as a public health …

Intestinal bacteria and colorectal cancer: etiology and treatment

MW Dougherty, C Jobin - Gut Microbes, 2023 - Taylor & Francis
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …