Ageing is a universal and unavoidable phenomenon that significantly increases the risk of
developing chronic kidney disease (CKD). It has been reported that ageing is associated …

Highlights•Aging transcriptomes consist of regulated and dysregulated gene expression
changes.•Dysregulated transcriptional changes can be random (noise) or non-random …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold
standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) …

Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering
now facilitate the study of the molecular underpinnings of disease in relevant human cell …

The evolutionary forces shaping life history divergence within species are largely unknown.
Turquoise killifish display differences in lifespan among wild populations, representing an …

The African turquoise killifish is an exciting new vertebrate model for aging studies. A
significant challenge for any model organism is the control over its diet in space and time. To …

Fat is historically associated with poor health and obesity. However, the continuous use of
lipidomics and genetic studies in model organisms revealed that specific lipid profiles and …

Lifespan is a remarkably diverse trait in nature, ranging from just hours in adult mayflies to
hundreds of years in the Greenland shark and quahog clam. Great disparities in lifespan are …

The genome of a eukaryotic cell is often vulnerable to both intrinsic and extrinsic threats
owing to its constant exposure to a myriad of heterogeneous compounds. Despite the …

Cardiac fibrosis and myocyte hypertrophy are hallmarks of the cardiac remodelling process
in cardiomyopathies such as heart failure (HF). Dyslipidemia or dysregulation of lipids …