Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

Immune responses to protein and peptide drugs can alter or reduce their efficacy and may
be associated with adverse effects. While anti-drug antibodies (ADA) are a standard clinical …

Peptide mimotopes of capsular polysaccharides have been proposed as antigens for
vaccines against encapsulated pathogens. In this study, we determined the antibody …

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …

Protein therapeutics hold a prominent role and have brought significant diversity in
efficacious medicinal products. Not just monoclonal antibodies and different antibody …

MHC-II-associated peptide proteomics (MAPPs) is a mass spectrometry-based (MS) method
to identify naturally presented MHC-II-associated peptides that could elicit CD4+ T cell …

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from
foreign pathogen products to abnormal cellular components such as in cancer. However, an …

One promising method to prevent vector-borne diseases is through the use of transmission
blocking vaccines (TBVs). However, developing several anti-pathogen TBVs may be …

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging
from immune pathology to drug design. Structural characterization of molecular partners has …

Protein conjugates of oligosaccharides or peptides that mimic complex bacterial
polysaccharide antigens represent alternatives to the classical polysaccharide-based …