Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …

The neuropathological and biological understanding of disease progression in multiple
sclerosis have progressed in the last few years. As a consequence, new therapeutic …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis (MS) and have implications for non-relapsing biological progression. In …

A large and expending body of evidence indicates that the gut-brain axis likely plays a
crucial role in neurological diseases, including multiple sclerosis (MS). As a whole, the gut …

Activation of innate immunity and deposition of blood-derived fibrin in the central nervous
system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple …

Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …

While the fundamental importance of the white matter in supporting neuronal communication
is well known, existing publications of primate brains do not feature a detailed description of …

The standard anatomical brain template provides a common space and coordinate system
for visualizing and analyzing neuroimaging data from large cohorts of subjects. Previous …