Cell division is tightly regulated to disentangle copied chromosomes in an orderly manner
and prevent loss of genome integrity. During mitosis, transcriptional activity is limited and …

Background HER2 is overexpressed and amplified in approximately 15% of invasive breast
cancers, and is the molecular target and predictive marker of response to anti-HER2 agents …

The kinetochore is a mega-dalton protein assembly that forms within centromeric regions of
chromosomes and directs their segregation during cell division. Here we review cell cycle …

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in
transcription, genome maintenance, and proteostasis. The contributions of many conserved …

Chromosome segregation depends on the kinetochore, the machine that establishes force-
bearing attachments between DNA and spindle microtubules. Kinetochores are formed …

The kinetochore is the macromolecular protein complex that mediates chromosome
segregation. The Dsn1 component is crucial for kinetochore assembly and is …

Cells are regularly exposed to stress conditions that may lead to protein misfolding. To cope
with this challenge, molecular chaperones selectively target structurally perturbed proteins …

The yeast Saccharomyces cerevisiae generally shows a low natural capability to utilize
glycerol as the sole source of carbon, particularly when synthetic medium is used and …

Chromosome segregation relies on forces generated by spindle microtubules that are
translated into chromosome movement through interactions with kinetochores, highly …

Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete
formation through meiosis requires that kinetochores take on new functions that impact …