[HTML][HTML] Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity
Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …
capacity. SCLC has been classified into molecular subtypes based on differential …
Small cells–big issues: biological implications and preclinical advancements in small cell lung cancer
A Solta, B Ernhofer, K Boettiger, Z Megyesfalvi… - Molecular cancer, 2024 - Springer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
Abstract KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
W Cui, M Guo, D Liu, P Xiao, C Yang, H Huang… - Nature Cell …, 2024 - nature.com
The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut
microbes participate in the progression of tumorigenesis through the generation of …
microbes participate in the progression of tumorigenesis through the generation of …
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
Abstract Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional
subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence …
subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence …
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth
L Guo, T Hong, YT Lee, X Hu, G Pan, R Zhao… - Nature cell …, 2024 - nature.com
The ten-eleven translocation (TET) family of dioxygenases maintain stable local DNA
demethylation during cell division and lineage specification. As the major catalytic product of …
demethylation during cell division and lineage specification. As the major catalytic product of …
[HTML][HTML] Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
Despite small cell lung cancers (SCLCs) having a high mutational burden, programmed
death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs …
death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs …
Genetically-engineered mouse models of small cell lung cancer: the next generation
Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in
dire need of new and effective therapeutic approaches. Modeling SCLC in an …
dire need of new and effective therapeutic approaches. Modeling SCLC in an …
[HTML][HTML] H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation
Cell fate determination is an intricate process which is orchestrated by multiple regulatory
layers including signal pathways, transcriptional factors, epigenetic modifications, and …
layers including signal pathways, transcriptional factors, epigenetic modifications, and …
Assessing next-generation sequencing-based computational methods for predicting transcriptional regulators with query gene sets
This article provides an in-depth review of computational methods for predicting
transcriptional regulators (TRs) with query gene sets. Identification of TRs is of utmost …
transcriptional regulators (TRs) with query gene sets. Identification of TRs is of utmost …