Bifunctional antimicrobial conjugates and hybrid antimicrobials

P Klahn, M Brönstrup - Natural product reports, 2017 - pubs.rsc.org
Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

Pseudomonas aeruginosa virulence attenuation by inhibiting siderophore functions

GJ Jeong, F Khan, S Khan, N Tabassum… - Applied Microbiology …, 2023 - Springer
Pseudmonas aeruginosa is a Gram-negative bacterium known to be ubiquitous and
recognized as one of the leading causes of infections such as respiratory, urinary tract …

Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition

Y Wang, JC Wilks, T Danhorn, I Ramos… - Journal of …, 2011 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa forms biofilms, which render it more
resistant to antimicrobial agents. Levels of iron in excess of what is required for planktonic …

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa

GLA Mislin, IJ Schalk - Metallomics, 2014 - academic.oup.com
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen responsible for
nosocomial infections. The prevalence of antibiotic-resistant P. aeruginosa strains is …

The Pseudomonas aeruginosa Pyochelin-Iron Uptake Pathway and Its Metal Specificity

A Braud, M Hannauer, GLA Mislin… - Journal of …, 2009 - Am Soc Microbiol
Pyochelin (Pch) is one of the two major siderophores produced and secreted by
Pseudomonas aeruginosa PAO1 to assimilate iron. It chelates iron in the extracellular …

The growing synthetic utility of the Weinreb amide

S Balasubramaniam, IS Aidhen - Synthesis, 2008 - thieme-connect.com
Abstract N-Methoxy-N-methylamide, popularly addressed as the Weinreb amide, has
surfaced as an amide with a difference. This amide has served as an excellent acylating …

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as Novel Anticancer Agents: Synthesis, biological evaluation, and structure− activity relationships

Y Lu, CM Li, Z Wang, CR Ross, J Chen… - Journal of medicinal …, 2009 - ACS Publications
A series of 4-substituted methoxybenzoyl-aryl-thiazoles (SMART) have been discovered and
synthesized as a result of structural modifications of the lead compound 2-arylthiazolidine-4 …

[HTML][HTML] Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

AK Ückert, S Rütschlin, S Gutbier, NC Wörz… - Environment …, 2023 - Elsevier
The causes of nigrostriatal cell death in idiopathic Parkinson's disease are unknown, but
exposure to toxic chemicals may play some role. We followed up here on suggestions that …

Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport

HM Behrens, ED Lowe, J Gault, NG Housden… - MBio, 2020 - Am Soc Microbiol
ABSTRACT Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human
pathogen Pseudomonas aeruginosa in animal infection models, but its import mechanism is …

Phenotypic adaption of Pseudomonas aeruginosa by hacking siderophores produced by other microorganisms

Q Perraud, P Cantero, B Roche, V Gasser… - Molecular & Cellular …, 2020 - ASBMB
Bacteria secrete siderophores to access iron, a key nutrient poorly bioavailable and the
source of strong competition between microorganisms in most biotopes. Many bacteria also …