Cetuximab and chemoradiation for rectal cancer–is the water getting muddy?
R Glynne-Jones, S Mawdsley, M Harrison - Acta Oncologica, 2010 - Taylor & Francis
The epidermal growth factor receptor (EGFR) inhibitor cetuximab has been successfully
combined with radical radiotherapy in head and neck cancer. In colorectal cancer, increased …
combined with radical radiotherapy in head and neck cancer. In colorectal cancer, increased …
The role of capecitabine in locally advanced rectal cancer treatment: an update
C Fernández-Martos, M Nogué, P Cejas… - Drugs, 2012 - Springer
Abstract Preoperative infusional 5-fluorouracil (5-FU) and concurrent radiation therapy (RT)
followed by total mesorectal surgery is the current standard of care for locally advanced …
followed by total mesorectal surgery is the current standard of care for locally advanced …
Medium-term results of neoadjuvant systemic chemotherapy using irinotecan, 5-fluorouracil, and leucovorin in patients with locally advanced rectal cancer
Y Ishii, H Hasegawa, T Endo, K Okabayashi… - European Journal of …, 2010 - Elsevier
AIMS: The aim of this study was to evaluate the usefulness of neoadjuvant systemic
chemotherapy using irinotecan, 5-FU, and leucovorin (LV) for the treatment of locally …
chemotherapy using irinotecan, 5-FU, and leucovorin (LV) for the treatment of locally …
[HTML][HTML] Current status of pharmacological treatment of colorectal cancer
R Akhtar, S Chandel, P Sarotra… - World journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To review the clinical trials for the development in drugs for chemotherapeutic treatment
of colorectal cancer (CRC). METHODS: A systematic review identified randomized …
of colorectal cancer (CRC). METHODS: A systematic review identified randomized …
[HTML][HTML] Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study
C Carlomagno, A Farella, L Bucci, FP D'Armiento… - Annals of oncology, 2009 - Elsevier
Background Preoperative chemoradiation is now standard treatment for stages II–III rectal
cancer. Capecitabine (CAP) and oxaliplatin (OX) are synergistic with radiotherapy (RT) and …
cancer. Capecitabine (CAP) and oxaliplatin (OX) are synergistic with radiotherapy (RT) and …
Preoperative chemoradiation with irinotecan and capecitabine in patients with locally advanced resectable rectal cancer: long-term results of a Phase II study
YS Hong, DY Kim, SB Lim, HS Choi, SY Jeong… - International Journal of …, 2011 - Elsevier
PURPOSE: Preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer has
shown benefit over postoperative CRT; however, a standard CRT regimen has yet to be …
shown benefit over postoperative CRT; however, a standard CRT regimen has yet to be …
T3+ and T4 rectal cancer patients seem to benefit from the addition of oxaliplatin to the neoadjuvant chemoradiation regimen
IS Martijnse, RL Dudink, M Kusters, TA Vermeer… - Annals of surgical …, 2012 - Springer
Background To achieve T-downstaging and better resectability in locally advanced rectal
cancer, neoadjuvant radiochemotherapy (RCT) has become the current standard of …
cancer, neoadjuvant radiochemotherapy (RCT) has become the current standard of …
Effect of neoadjuvant cetuximab, capecitabine, and radiotherapy for locally advanced rectal cancer: results of a phase II study
PL Sun, B Li, QF Ye - International journal of colorectal disease, 2012 - Springer
Purpose The aim of this study was to investigate the efficacy and safety of neoadjuvant
cetuximab, capecitabine, and radiotherapy for patients with locally advanced rectal cancer …
cetuximab, capecitabine, and radiotherapy for patients with locally advanced rectal cancer …
Oxaliplatin as a radiosensitiser for upper and lower gastrointestinal tract malignancies: what have we learned from a decade of translational research?
EJ Hill, NH Nicolay, MR Middleton… - Critical reviews in oncology …, 2012 - Elsevier
Some of the greatest advances in the treatment of solid malignancies have resulted from the
combination of chemotherapy and radiotherapy treatments. This article comprehensively …
combination of chemotherapy and radiotherapy treatments. This article comprehensively …
Optimizing neoadjuvant therapy for rectal cancer with oxaliplatin
LK Martin, T Bekaii-Saab - Journal of the National Comprehensive Cancer …, 2013 - jnccn.org
Neoadjuvant chemoradiation (CRT) is standard treatment for stage II-III rectal cancer.
Fluoropyrimidine-based CRT prolongs disease-free survival over adjuvant CRT and …
Fluoropyrimidine-based CRT prolongs disease-free survival over adjuvant CRT and …